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  • Thursday, 15th

     10:00 MEETING REGISTRATION OPENS
     10:30 - 12:30 PRE-MEETING SYMPOSIUM: ORAL PRESENTATIONS
    Moderador:     James Hutchinson
    13:00 - 14:00 LUNCH BREAK
    14:00 - 16:00 POSTER PRESENTATIONS
    Moderadores:     Sandra Pascual, Pascual Martínez
    17:00 - 17:30 SYMPOSIUM WELCOME
    • Amparo Navarro Faure: Dean of the University of Alicante (UA)
    • Cristóbal Belda Iniesta: Director of the Spanish Institutes of Health Carlos III (ISCIII)
    • Jordi Cano Ochando: President of the Sympposium (A-WISH)
    17:30 - 20:00 SESSION 1. OVERVIEW OF TRAINED IMMUNITY
    Moderator:     Paloma Riquelme

    Adventurers in Immunometabolism Research
    Keynote Speaker: Luke O'Neil. Trinity College Dublin, Ireland

    Trained immunity in lymphoid cells
    Shabaana Khader. Washington University in St.Louis, USA

    A brief history of lncRNAs and Innate Immune Memory
    Musa Mhlanga. Radboud University Medical Center, The Netherlands

    Trained immunity in atherosclerosis.
    Siroon Bekkering. Radboud University Medical Center, the Netherlands.

    Central trained immunity and the role of bone marrow
    Triantafyllos Chavakis. Technische Universitat Dresden, Germany

    O-01. IL-10 engineered DC modulate B cell responses in vitro.

    Morali, Konstantina1; Steuten, Juulke2; Ten Brinke, Anja3; Van Ham, Marieke3; Gregori, Silvia4.

    1San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan; 2Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, Amsterdam; 3Department of Immunopathology, Sanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, Amsterdam; 4San Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.

    O-02. Effects of small molecule modulators of mitochondrial respiratory complex iii on cytokine production in macrophages.

    Zotta, Alessia1; Palsson Mcdermott, Eva M.1; Day, Emily A.1; Escher Toller, Juliana1; Ryan, Dylan G.2; Miljkovic, Jan2; Murphy, Michael P.2; Watson, Mark A.3; Brand, Martin D.3; O' Neill, Luke A.j.1.

    1Trinity College Dublin, Dublin; 2University of Cambridge, Cambridge; 3The Buck Institute for Research on Aging, Novato.

    O-03. MS inflammation alters the epigenetic profile of peripheral CD14+ cells affecting the generation of an optimal VitD3-TolDCs therapy.

    Fondelli, Federico1; Mansilla, Maria José1; Godoy Tena, Gerard2; Presas Rodriguez, Silvia3; Ramo Tello, Cristina3; Ballestar, Esteban2; Martinez Caceres, Eva3.

    1Institut German Trias i Pujol, Badalona; 2Institut Josep Carreras, Badalona; 3Hospital German Trias i Pujol, Badalona.

    O-04. Targeting Mreg-T cell interactions in Transplantation

    Cordero, Laura1; Timosenko, Elina2; Mallorqui-Fernandez, Noemi2; Rust, Steven2; Hutchinson, James1; Riquelme, Paloma1.

    1University Hospital Regensburg, Regensburg; 2AstraZeneca, Cambridge Biomedical Campus.

    O-05. Development of an in-vitro trained immunity protocol in mice.

    Gonzalez Perez, Maria; Conde, Patricia; Cano Ochando, Jordi.

    Instituto de Salud Carlos III, Madrid (CNM).

    O-06. Epigenetic reprogramming underlies immunogenic switch in macrophages during activation in hypoxia

    De La Calle-Fabregat, Carlos; Calafell-Segura, Josep; Ciudad, Laura; Rodríguez-Ubreva, Javier; Ballester, Esteban.

    Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), Badalona.

  • Friday, 16th

     09:30 - 11:30 SESSION 2. TRAINED IMMUNITY AND VACCINES
    Moderator:     África Gonzalez

    Heterologous effects of vaccines on health.
    Christine Stabell - Benn. University of Southern Denmark, Denmark

    MV130 as a trained immunity-based vaccine: mechanism of action and clinical impact.
    Carlos del Fresno, Hospital La Paz Institute for Health Research, Spain

    MTBVAC entry into TB efficacy trials and exploration of non-specific effects compared to BCG.
    Carlos Martín. University of Zaragoza, Spain

    Protection of adapted vaccines to omicron: more certainties than doubts.
    Eva Polverino. University Hospital Vall d'Hebron, Spain
     11:30 - 12:00 Coffee break
    12:00 - 14:30 SESSION 3. DEVELOPMENT AND REGULATION OF INNATE IMMUNE CELLS
    Moderator:     Carmen Camara

    Myeloid cell mediated linkage between local inflammation and tissue homeostasis
    Dietmar Zaiss. University of Regensburg, Germany.

    Post-COVID19 trained immunity.
    Steven Josefowicz. Cornell University, USA.

    Genetic and epigenetic characterization of tolerogenic DC-10
    Silvia Gregori. San Raffaele Scientific Institute, Italy.

    Calcineurin/NFAT Signalling Regulates β-glucan Induced Trained Immunity
    David Sancho. Spanish National Cardiovascular Research Center (CNIC), Madrid, Spain.

    Development of Myeloid cells
    Florent Ginhoux. Gustave Roussy Hospital, Villejuif, France.
    14:30 - 15:30 LUNCH BREAK
    15:30-17:30 SESSION 4. TARGETING AND VISUALIZING THE INNATE IMMUNE SYSTEM
    Moderator:     María González

    Targeting innate immunity to treat disease
    Willem Mulder. Eindhoven University of Technology, The Netherlands

    In vivo imaging of the immune system for health and disease assessment
    Zahi Fayad. Icahn School of Medicine at Mount Sinai, New York, USA

    Trained immunity in mycrobacterial infections
    Maziar Divangahi. McGill University, Canada

    Trained immunity: a memory for innate host defense
    Mihai Netea. Radboud University Medical Center, the Netherlands
    17:30 - 18:00 COFFEE BREAK
    18:00 - 19:00 CLOSING SESSION. INNATE IMMUNITY AND HEALTH
    Moderador:     Mihai Netea

    Innate immunity in health and disease
    Akiko Iwasaki. Yale School of Medicine and Howard Hughes Medical Institute, USA

    Discovery of toll-like receptors
    Ruslan Medzhitov. Yale School of Medicine and Howard Hughes Medical Institute, USA
    19:00 - 20:00 AWARD CEREMONY
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